SAT is governed by a skills-based Board that provide strategic direction through biannual meetings. The majority of the Board members are actively working with HIV and AIDS issues in the southern African region. The Board has established committees ( executive, legal and finance) to handle matters in between board meetings. At country level, the regional Board has established advisory committees to ensure SAT's relevance to the national context.
| Connie Mutunhu | Chair |
| Kholeka Mzondeki | Treasurer |
| Miriam Banda | Board member |
| Antonica Hembe | Board member |
| Brenda Kahari | Board member |
| Chitsike Inam | Board member |
| Anthony Kinghorn | Board Member |
| Daniel Mullins | Board member |